Cofilin may be early culprit in tauopathy process leading to brain cell death

Cofilin may be early culprit in tauopathy process leading to brain cell death. by University of South Florida

Cofilin may be early culprit in tauopathy process leading to brain cell death Written by Anne DeLotto Baier May 13, 2019 @ 4:54 pm Filed under Byrd Alzheimer’s Institute , Morsani College of Medicine , Neurosciences & Brain Repair , News Releases , Research , School of Biomedical Sciences

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Schematic-activated cofilin-tauopathy-600400. Written by Anne DeLotto Baier May 13, 2019 @ 4:46 pm Filed under.

Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the. The major tau protein in the human brain is encoded by 11 exons.. of Alzheimer's disease, frontotemporal dementia, and other tauopathies.. cytoplasmic functions and interferes with axonal transport, which can lead to cell death.

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Abstract: EFhd2 is a calcium-binding adaptor protein that has been found to be associated with pathologically aggregated tau in the brain in Alzheimer disease and in a mouse model of frontotemporal.

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Cofilin may be early culprit in tauopathy process leading to brain cell death Abnormal accumulations of amyloid plaques and tau neurofibrillary tangles are both needed to drive the death of brain cells, or neurons.

Researchers have identified a new group of enzymes that appear to control how cells direct internal traffic and regulate certain types of locomotion, according to a report in the May 12 online edition.

Cofilin may be early culprit in tauopathy process leading to brain cell death IMAGE: Neurofibrillary tau tangles (stained red) are one of the two major brain lesions of Alzheimer’s disease. blue fluorescent stain (dapi) depicts the nerve cell nuclei.